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沙发
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发表于 2022-1-30 19:06:23
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4. 讨论
目前的研究结果证实了赛拉菌素+沙罗拉纳的新滴剂配方在最小标签剂量下对跳蚤的高效杀灭作用且至少持续五周。结果表明该产品在使用后 12 小时内就开始杀灭跳蚤,且随后在一个月内再次跳蚤感染后的6 小时内就开始杀灭跳蚤。
猫跳蚤控制的主要目标是迅速杀死跳蚤,以快速缓解与跳蚤相关的临床症状,例如瘙痒和跳蚤过敏性皮炎 (FAD)。 此外,跳蚤需要在 24 小时内被杀死,因为24小时后跳蚤就开始产卵、污染环境并开始跳蚤的生命周期(Rust 和 Dryden,1997)。为了降低疾病传播的风险并打破这些蚤媒疾病的流行病学循环,还需要快速的杀虫作用。 赛拉菌素+沙罗拉纳新滴剂在给药后12小时内和跳蚤再次感染后6小时内开始杀灭跳蚤。 众所周知,赛拉菌素的快速杀灭作用与单次治疗后至少28天的跳蚤吸血量显著减少(88.9%–97.4%)相结合,从而减少了 FAD 症状(McCoy et 等,2008)。 相比之下,在同一研究中,非泼罗尼治疗对跳蚤吸血的显著影响仅有7 天,而吡虫啉仅 有14 天。
跳蚤治疗不仅预期快速起效,而且还能提供长期、持久的功效,以保护动物免受环境中跳蚤的再次感染。与这些预期一致,目前的研究表明,赛拉菌素/沙罗拉纳在单次给药后至少5周内,对猫的跳蚤感染提供了高效的治疗和持续控制。该结果与单独含有赛拉菌素的外用制剂对跳蚤表现出一致的高效性(McTier 等,2000a,b;Dryden 等,2004;Schenker 等,2003;Franc 和 Yao,2007)。赛拉菌素还具有持久的杀蚤卵和杀幼虫作用(McTier 等, 2000b),赛拉菌素/沙罗拉纳也几乎完全抑制产卵(Vatta 等 , 2017)。赛拉菌素/沙罗拉纳快速持久的药效与其对跳蚤繁殖的强效作用相结合,快速持久地打破跳蚤的生命周期,降低猫在家庭环境中的感染风险,提供全面的对跳蚤的防护。赛拉菌素/沙罗拉纳的高效快速疗效的影响也在临床条件下得到证实,该治疗也成功地减少了客户拥有的猫的 FAD 临床症状(Geurden 等, 2017 )。
5. 结论
以推荐的最小剂量单次局部给药赛拉菌素 + 沙罗拉纳新滴剂配方,可快速、高效地治疗现存的跳蚤感染,并可持续一个月控制猫身上的跳蚤。单次给药可以在 12 小时内开始杀灭现有的跳蚤,并在随后的再次感染的 6 小时内开始杀灭跳蚤。
利益冲突
此处报告的研究由硕腾资助。 CB、JAC、AFV、VLK、DL 和 DR 是硕腾的现任员工或在研究时受雇于硕腾。所有作者都参与协助研究的设计和实施、数据的解释和手稿审查。没有可能影响这些研究的实施和报告的利益冲突。
致谢
作者要感谢 Heidi Erasmus、William Russell Everett 和 Otto Cuppens 在开展研究过程中提供的帮助。
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