Cutaneous lupus erythematosus in dogs: a comprehensive review 犬皮肤红斑狼疮：一项综合性评估 作者：Thierry Olivry , Keith E. Linder and Frane Banovic
翻译：辛蕾 校对：王帆
Abstract
Since the first description of discoid lupus erythematosus (LE) in two dogs in 1979, the spectrum of canine cutaneous lupus erythematosus (CLE) variants has expanded markedly.
In this review, we first propose an adaptation of the Gilliam-Sontheimer classification of CLE for dogs. We then review the signalment, clinical signs, laboratory and histopathology and treatment outcome of the currently recognized variants of canine CLE, which are vesicular CLE, exfoliative CLE, mucocutaneous LE and facial or generalized discoid LE.
We end with a short description of the rare cutaneous manifestations of systemic LE in dogs.
Canine CLE variants are heterogeneous, some of them mirror their human counterparts while others appear—thus far—unique to the dog. As most CLE subtypes seem to have a good prognosis after diagnosis, veterinarians are encouraged to become familiar with the spectrum of often-characteristic and unique clinical signs that would permit an early diagnosis and the rapid implementation of an effective treatment. Keywords: Auto-immune skin diseases, Auto-immunity, Canine, Dermatology, Lupus, Skin 摘要
从1979年第一次对两只犬的盘状红斑狼疮（LE）进行描述以来，犬皮肤红斑狼疮（CLE）变种范围明显扩大。
在这篇综述中，我们首先提出了犬皮肤红斑狼疮的Gilliam-Sontheimer分类法。之后我们回顾了目前公认的不同种犬皮肤红斑狼疮的特征、临床症状、实验室检查和组织病理学检查以及治疗效果，包括了水疱型皮肤红斑狼疮、表皮剥脱型皮肤红斑狼疮、黏膜皮肤红斑狼疮以及面部或全身型盘状红斑狼疮。
最后我们简短地描述了犬系统性红斑狼疮的罕见皮肤表现。
犬皮肤红斑狼疮的变异型多种多样,其中一些与人类相似，而另一些只在犬中出现。由于大多数皮肤红斑狼疮亚型在诊断后似乎有良好的预后，鼓励兽医们去熟悉常见和罕见的临床症状，这便于早期的诊断和快速实施有效的治疗。 关键词：自体免疫性皮肤病、自体免疫性、犬、皮肤病学、狼疮、皮肤
